In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2688-84-8, name is 2-Phenoxyaniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 2688-84-8
To a 1 L four-necked round bottom flask equipped with a stirrer, a Liebig condenser fitted with a calcium chloride tube, a nitrogen inlet tube, a 50 mL isobaric dropping funnel and a thermometer, 50.0 g (0.6 mmol) of 2′-phenoxyaniline was added. 27 mol) and 500 mL of DCM, and the mixture was stirred at room temperature under a nitrogen stream. Subsequently, 42.8 g (0.41 mol) of triethylamine was added, and the mixture was cooled to -10 C. with an ice water bath, and 30.3 g (0.38 mol) of acetyl chloride was added dropwise from the dropping funnel at 0 C. or less while paying attention to heat generation . The mixture was further stirred at the same temperature for 30 minutes, returned to room temperature, and allowed to react after 5 hours to obtain a reaction solution.Next, 250 g of pulverized ice was added to a 1 L four-necked round bottom flask equipped with a stirrer, a Liebig condenser fitted with a calcium chloride tube, a 1 L dropping funnel and a thermometer, and while stirring, the above reaction solution The whole amount was added dropwise. Next, the dropping funnel was washed with 100 mL of DCM and added to the reaction solution, followed by stirring at room temperature for one day and night.The obtained reaction solution was transferred to a 1 L separating funnel, the organic layer was separated, washed three times with 250 mL of water, dried with magnesium sulfate, magnesium sulfate was suction filtered and removed, And the solvent was distilled off to obtain 73.2 g (yield 119.8%) of the target compound. The obtained compound was directly used for the next reaction.
The synthetic route of 2688-84-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; YAMAGATA UNIVERSITY; CHEMIPRO KASEI KAISHA LIMITED; KIDO, JUNJI; SASABE, HISAHIRO; TAKAHASHI, JUN; NAGAI, NAGAI; (723 pag.)JP2018/90561; (2018); A;,
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