Application of 19500-02-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 19500-02-8, name is 3-Methoxy-2-methylaniline, This compound has unique chemical properties. The synthetic route is as follows.
To a solution of 2-methyl-3-(methyloxy)aniline (5.0 g, 36.5 mmol) in p-xylene (80 mL) and cooled to 0¡ã C., added BCl3 (36.5 mL) as a 1M solution in dichloromethane and stirred for 30 min at 0¡ã C. under a nitrogen atmosphere. Acetonitrile (2.6 mL, 54.7 mmol) was added and the solution was stirred for an additional 30 min at 0¡ã C. AlCl3 (4.87 g, 36.5 mmol) was suspended in anhydrous dichloromethane (50 mL) under a nitrogen atmosphere and cooled to 0¡ã C. The xylene solution was transferred to an addition funnel and added to the dichloromethane reaction dropwise. The reaction was stirred at 0¡ã C. for 45 min and the dichloromethane was removed in vacuo. The xylene solution was heated to 70¡ã C. for 18 h and cooled to room temperature. Water (80 mL) was added and the solution was heated to 70¡ã C. for 1 h and cooled to room temperature. The reaction was diluted with ethyl acetate and the aqueous layer separated. The organic layer was washed with an equal volume of water, brine and dried (MgSO4) and concentrated in vacuo. To the residue was added 5:1 hexanes:diethyl ether and the precipitate collected by filtration to afford intermediate 9 as a white solid (4.66 g, 71percent yield). 1H NMR (400 MHz, DMSO-d6) delta ppm 1.87 (s, 3H) 2.42 (s, 3H) 3.77 (s, 3H) 6.30 (d, J=9.04 Hz, 1H) 7.03 (br. s., 2H) 7.65 (d, J=9.04 Hz, 1H). LC-MS (ESI): m/z 180.10 (M+H)+.
The chemical industry reduces the impact on the environment during synthesis 3-Methoxy-2-methylaniline. I believe this compound will play a more active role in future production and life.
Reference:
Patent; GLAXOSMITHKLINE LLC; US2010/196321; (2010); A1;,
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