Related Products of 18800-30-1, These common heterocyclic compound, 18800-30-1, name is 1-Bromo-4-(2-bromoethoxy)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 1-bromo-4-(2-bromoethoxy)benzene (19.9 g, 100 mmol; see step (a) above) in THF (120 mL) was portion-wise added t-BuOK (14.0 g, 125 mmol) over 10 min at 0C. After stirring at room temperature for 16 h, the mixture was diluted with ‘water (400 mL) and the product was extracted with light petrol (4×100 mL). The combined organic extracts were washed with brine, dried (Na(at)S04), concentrated and distilled under vacuum to yield the sub-title compound (11.5 g, 58%).
The synthetic route of 18800-30-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BIOLIPOX AB; WO2005/123673; (2005); A1;,
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