Synthetic Route of 202865-80-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 202865-80-3, name is 4-Bromo-2-fluoro-1-isopropoxybenzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Potassium acetate ( 10.52 g, 107.2 mmol) and bis(pinacolato)diboron ( 15g, 58.96 mmol) were added to a solution of intermediate 11 ( 10.52 g, 107.2 mmol) in dioxane ( 125 ml), and the solution was degassed for 30 min. [1, 1 ‘- Bis(diphenylphosphino)ferrocene]dichloro palladium(II).CH2Cl2 (4.4g, 5.36 mmol) was added under nitrogen atmosphere and heated to 80C. After 12h the reaction mixture was filtered through celite and concentrated. The crude product was purified by column chromatography with ethyl acetate: petroleum ether to afford the title compound as a yellow oil ( 13.9g, 99%) which was used without purification in the next step.
The synthetic route of 4-Bromo-2-fluoro-1-isopropoxybenzene has been constantly updated, and we look forward to future research findings.
Reference:
Patent; RHIZEN PHARMACEUTICALS SA; NAGARATHNAM, Dhanapalan; VAKKALANKA, Swaroop Kumar, V.S.; MUTHUPPALANIAPPAN, Meyyappan; VISWANADHA, Srikant; BABU, Govindarajulu; BHAVAR, Prashant, Kashinath; WO2012/151525; (2012); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem