Adding a certain compound to certain chemical reactions, such as: 10541-78-3, name is 2-Methoxy-N-methylaniline, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 10541-78-3, Quality Control of 2-Methoxy-N-methylaniline
This compound was obtained by reacting 2-methoxy-N-methylaniline (3.0 g, 21.9 mmol.) and cyclopentanone (9.20 g, 109mmol) in the presence of a catalytic amount of iodine (278 mg, 1.09 mmol).After purification on a silica gel column using hexanes-ethyl acetate (95: 5),compound 10a was obtained as a yellowish oil (2.35 g, 42%). 1H NMR (CDCl3, 400 MHz): delta 1.68-1.72(2H, m), 1.76-1.82 (2H, m), 1.85-1.92 (2H, m), 2.01-2.07 (2H, m), 2.51-2.56(2H, m),2.65-2.70 (2H, m), 4.05 (3H, s), 4.47 (1H, brs, NH), 5.01 (1H, m), 6.03(1H, m), 6.58 (1H, d, J = 7.6 Hz),6.60 (1H, d, J = 4.0 Hz), 6.65 (1H,dd, J = 7.6 and 4.0 Hz). 13CNMR (CDCl3, 100 MHz): delta 22.6, 24.1, 31.6, 32.4, 40.2, 55.8, 64.8,109.3, 115.9, 116.3, 120.5, 132.2, 132.3, 138.8, 145.4. EI-MS (GC-MS): m/z(5) 255 [M]+ (30), 227(100), 213(15)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Methoxy-N-methylaniline, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Fotie, Jean; Ayer, Suraj K.; Poudel, Binit S.; Reid, Carolyn S.; Tetrahedron Letters; vol. 54; 51; (2013); p. 7069 – 7073;,
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