Some common heterocyclic compound, 7664-66-6, name is 4-Isopropoxyaniline, molecular formula is C9H13NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 4-Isopropoxyaniline
Synthesis of compound 126.1. To a solution of 2.5 (0.30 g, 0.96 mmol, 1.0 eq) in dry CH3CN (5mL) were added 4-isopropoxyaniline (0.145g, 0.96mmol, l .Oeq), and DIPEA (0.49 mL, 2.88 mmol, 3. Oeq). Reaction mixture was allowed to stir at 100 C for 24 hours. After completion of the reaction, the mixture was cooled to room temperature. Water (10 mL) was added to the mixture and extracted with EtOAc. Organic layer was washed with brine, dried over sodium sulfate and concentrated under reduced pressure to give crude which was purified by column chromatography to afford compound 126.1 (0.300g, 73.15%). MS (ES): m/z = Ml A [M+H]+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 7664-66-6, its application will become more common.
Reference:
Patent; NIMBUS LAKSHMI, INC.; MASSE, Craig E.; GREENWOOD, Jeremy Robert; ROMERO, Donna L.; HARRIMAN, Geraldine C.; WESTER, Ronald T.; SHELLEY, Mee; KENNEDY-SMITH, Joshua Jahmil; DAHLGREN, Markus; WO2015/131080; (2015); A1;,
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