Research on new synthetic routes about 2-Methoxy-N-methylaniline

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 10541-78-3, its application will become more common.

Some common heterocyclic compound, 10541-78-3, name is 2-Methoxy-N-methylaniline, molecular formula is C8H11NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C8H11NO

Intermediate 36a (24 mg. 0.092 mmol), 2-methoxy- N-methylaniline (16 mg, 0.11 mmol), HAITI (38 mg, 0.10 mmol), and DIEA (64 sL, 0.37 mmol) were all combined in MeCN (1 mL) and stirred for 24 h at room temperature. The solution was then purified by preparative HPLC with a CIS silica gel stationary phase using a gradient of H20 0.05% TFA : CH3CN 0.05% TFA (70 :30 to 5 : 95) and detection by U V at 254 nm to give the title compound (18 mg, 52%) as a while solid. MS (ES, m/zy. 380 [M+if. 1H-NMR (400 MHz, CDCI3) delta 7.30-7.22 (m, 1H), 7.22-7.13 (m, 2H), 7.09 (d, J = 8.3 Hz, 1H), 6.88 (t, J- 7.5 Hz, I H), 6.68 (Patent; ARDELYX, INC.; LEWIS, Jason, G.; REICH, Nicholas; CHEN, Tao; JACOBS, Jeffrey W.; CHARMOT, Dominique; NAVRE, Marc; FINN, Patricia; CARRERAS, Christopher; SPENCER, Andrew; WO2013/96771; (2013); A1;,
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