In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 17061-62-0 as follows. Recommanded Product: Bis(4-methoxybenzyl)amine
To a solution of 2-chloroethanesulfonyl chloride (2mL, 19 mmol) in dichloromethane (95 mL) was added dropwise triethylamine (2.64 mL, 19 mmol) at -72C under argon. The resulting mixture was stirred at this temperature for 10 min. Then the reaction mixture was warmed to room temperature and stirred for 2h. After this time bis-(4-methoxybenzyl)-amine (4.94 g, 19 mmol) and TEA (3.17 mL, 23 mmol) were added at 0C. After stirring at room temperature for 2 h the solvent was evaporated to give 6.87 g of the crude product (100%). 1H NMR (700 MHz, Chloroform-d) delta 7.27 – 7.19 (m, 4H), 6.93 – 6.88 (m, 4H), 6.32 (dd, J = 16.5, 9.8 Hz, 1H), 6.22 (d, J = 16.5 Hz, 1H), 5.87 (d, J = 9.8 Hz, 1H), 4.22 (s, 4H), 3.84 (s, 6H). The crude product was used to the next step without any further purification.
According to the analysis of related databases, 17061-62-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ONCOARENDI THERAPEUTICS SP. Z O.O.; B?ASZCZYK, Roman; BRZEZI?SKA, Joanna; GO??BIOWSKI, Adam A.; OLCZAK, Jacek; (93 pag.)WO2016/108707; (2016); A1;,
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