In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1516-96-7 as follows. name: 5-Bromo-1,3-di-tert-butyl-2-methoxybenzene
To a 300 mL pressure bottle was added 5-bromo-1,3-di-tert-butyl-2-methoxybenzene (26 g, 87 mmol).Trimethyl ethynyl silicon (14.1 mL, 100 mmol), cuprous iodide (332 mg, 1.74 mmol),Triphenylphosphine palladium dichloride (611 mg, 0.87 mmol), triethylamine (60 mL),The mixture was reacted at 75 C for 12 h, cooled to room temperature, filtered and concentrated and applied directly to next.
According to the analysis of related databases, 1516-96-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Chinese Academy Of Sciences Shanghai Organic Chemistry Institute; Shi Shiliang; Cai Yuan; Yang Xintuo; Li Feng; (67 pag.)CN109776422; (2019); A;,
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