Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 458-03-7, name is 1-Ethoxy-3-fluorobenzene, A new synthetic method of this compound is introduced below., Recommanded Product: 1-Ethoxy-3-fluorobenzene
First Step In a reaction vessel under a nitrogen atmosphere, 14.5 g (103 mmol) of 1-ethoxy-3-fluorobenzene (No. 1) was dissolved into 150 mL of THF. At a temperature of -70 C. or lower, 100 mL (102 mmol) of s-butyllithium (1.02 M cyclohexane solution) was added dropwise to the solution, and the resultant mixture was stirred for 1 hour, and then a THF (50 mL) solution of 14.0 mL (110 mmol) of trimethylsilyl chloride was added dropwise thereto. The resultant mixture was stirred for 1 hour, and then the reaction mixture was poured into 300 mL of aqueous solution of ammonium chloride subjected to ice-cooling, and then liquids were separated. An aqueous layer was extracted with 100 mL of hexane twice, organic layers were combined, washed with water and saturated brine, dried over anhydrous sodium sulfate, and then a solvent was evaporated under reduced pressure. A residue was treated on silica gel column chromatography (silica gel:400 g, eluate:heptane), and then subjected to vacuum distillation (136 C., 50 mmHg), and thus 14.1 g (66.2 mmol, yield 64 mol %) of 1-ethoxy-3-fluoro-trimethylsilylbenzene (No. 2) was obtained.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.