Synthetic Route of 10541-78-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 10541-78-3, name is 2-Methoxy-N-methylaniline, This compound has unique chemical properties. The synthetic route is as follows.
To a mixture of 2-methoxyl-N-methylaniline (27.7 mg, 0.2 mmol) and Et3AI (196 mul_, 1.9 M in toluene, 0.2 mmol) in 1 ,2-dichloroethane (1 mL) which was preheated at 50 0C for 10 min under N2 atomsphere, was added 4-chloro-5-(4-cyano-6- trifluoromethyl-pyridin-3-yl)-2-methoxy-benzoic acid methyl ester (50 mg, 0.14 mmol ). The mixture was sealed in N2 atomsphere and heated at 80 0C for 16 hrs. Upon cooling to rt, the mixture was quenched with 2 N HCI (5 mL) and diluted with 1 ,2- dichloroethane. The organic layer was separated and concentrated. The residue was purfied via reverse phase preparative LCMS to yield 4-chloro-5-(4-cyano-6- trifluoromethyl-pyridin-3-yl)-2-methoxy-N-(2-methoxy-phenyl)-N-methyl-benzamide 38- 1 (4.9 mg). MS [M+H]+ 475.9; tR = 5.91 min (method 3)
The chemical industry reduces the impact on the environment during synthesis 2-Methoxy-N-methylaniline. I believe this compound will play a more active role in future production and life.