Extended knowledge of 4-Methoxy-N-methylbenzylamine

The chemical industry reduces the impact on the environment during synthesis 4-Methoxy-N-methylbenzylamine. I believe this compound will play a more active role in future production and life.

Reference of 702-24-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 702-24-9, name is 4-Methoxy-N-methylbenzylamine, This compound has unique chemical properties. The synthetic route is as follows.

A mixture of ethyl 8-bromo-6-chloroimidazo [1 ,2-b]pyridazine-3 -carboxylate (WO2009/100375) (5 g, 16.42 mmol), 1-(4-methoxyphenyl)-N-methylmethanamine (3.23 g,21.34 mmol), and N,N-diisopropylethylamine (5.74 ml, 32.8 mmol) in 1,4-dioxane (30 ml) was heated at 90 °C for 5 h. The volatiles were removed under vacuum. The residue was diluted with ethyl acetate (200 mL), washed with water (2 x 50 mL) and brine (50 mL), and dried over anhydrous Mg504. The desired product, ethyl 6-chloro-8-((4-methoxybenzyl)(methyl)amino)imidazo[ 1 ,2-b]pyridazine-3 -carboxylate (6.10 g, 16.27 mmol, 99 percent yield), was isolated as a pale yellow solid by ISCO (330 g silica gel, solid loading, 20-40percent ethyl acetate/hexane).

The chemical industry reduces the impact on the environment during synthesis 4-Methoxy-N-methylbenzylamine. I believe this compound will play a more active role in future production and life.