Adding a certain compound to certain chemical reactions, such as: 62415-74-1, name is 1,2-Dibromo-4-methoxybenzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 62415-74-1, name: 1,2-Dibromo-4-methoxybenzene
The zinc reagent 2b was prepared according to TP1 from 1,2-dibromo-4-methoxybenzene (1b, 3.98 g, 15 mmol), Zn-powder(2.94 mg, 45 mmol) and InCl3 (0.25 g, 1.13 mmol). The reaction was carried out in 15 mL DMPU at 50 C for 2 h. Iodolysis indicated a yield of 59% bimetallic reagent (8.85 mmol). The solution containing the zinc reagent was separated from the remaining zinc powder and transferred to a new flask containing a solution of methyl 4-iodobenzoate (3k, 788 g,30 mmol) and PEPPSI-iPr (0.14 g, 0.21 mmol) in THF (15 mL).The reaction mixture was stirred at 50 C for 12 h before being quenched with HCl (2 M, 40 mL). Flash column chromatographical purification on silica gel (pentane/diethylether = 5:1) afforded 4m as a white solid (2.37 g, 6.29 mmol,71%).
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