Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 70627-52-0, name is N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline
The raw material (III) (10 g, 28.0 mmol)And the starting material (IV) (17 g, 55.7 mmol)Was added to a 500 mL three-necked flask,Installed thermometer,Addition funnel and drying tube,Dry methylene chloride (150 mL) was added,The mixture was cooled to -20 C.Diisopropylethylamine (5.8 mL, 33.3 mmol) was added,Temperature control to -30 .Isopropyl titanate (3.0 mL, 10 mmol) was added,Maintaining the temperature at -25 C to -30 C,Titanium tetrachloride (3.3 mL, 30 mmol) was added dropwise.Control temperature <-25 ,The reaction was stirred for 5 hours,The reaction end point was detected by TLC.A mixed solution of slow acetic acid / dichloromethane (10 ml / 10 ml) was added to the reaction mixture,Drop add 2N sulfuric acid 30ml,The temperature was raised to 30 C for 30 minutes,Add water 30ml,Take the organic layer,The aqueous layer was extracted with 50 ml of dichloromethane,Combined organic layer,Followed by water 50ml,Saline 50ml washing,Dried over anhydrous sodium sulfate.After the solvent was distilled off,Add methanol 50ml,Reflux evenly,Standing slowly inside temperature 35 ,filter,The filter cake was washed with methanol 10 ml x 2,The solid was added to 50 ml of methanol,Reflux for 4 hours,Standing slowly cooled to the internal temperature of 40 ~ 45 ,filter,Filter cake with a small amount of methanol washing,Dried to a white solid (11.3 g, 17.1 mmol)Yield 60.9%. According to the analysis of related databases, 70627-52-0, the application of this compound in the production field has become more and more popular.