Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 74137-36-3, name is 1,3-Dibromo-5-methoxybenzene, A new synthetic method of this compound is introduced below., Formula: C7H6Br2O
The mixture of 1,3-dibromo-5-methoxybenzene (0.5 g,1.88 mmol), bis(pinacolato)diboron (1.05 g, 4.1 mmol), PdCl2(dppf)(140 mg, 0.23 mmol), potassium acetate (1.1 g,11.3 mmol), and DMF(40 mL) were stirred for 2.5 h at 80 C. The solvent was removed invacuo and the residue was dissolved in CH2Cl2. The solution waswashed with water and dried over magnesium sulfate. The filtratewas concentrated to dryness, and the residue was purified by flashcolumn chromatography on silica gel (eluent: petroleum ether/CH2Cl2 = 10/1), gave compound 3 as a white solid. Yield: 383 mg(56%). 1H NMR (400 MHz, CDCl3) delta (ppm): 7.87 (s, 1H), 7.42 (d,J 0.9 Hz, 2H), 3.84 (s, 3H), 1.33 (s, 24H). 13C NMR (100 MHz, CDCl3) delta (ppm): 158.56, 133.60, 122.79, 83.78, 55.33, 24.87. MS (EI): m/z 359.9.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.