Reference of 1535-73-5, The chemical industry reduces the impact on the environment during synthesis 1535-73-5, name is 3-Trifluoromethoxyaniline, I believe this compound will play a more active role in future production and life.
General procedure: To the stirred mixture of benzaldehyde (0.20 mL, 2.0 mmol) and amine (2.0 mmol, aniline: 0.18 mL, 4-toluidine: 0.21 g, biphenyl-4-amine: 0.34 g, 4-fluoroaniline: 0.19 mL, 4-chloroaniline: 0.26 g, 4-bromoaniline: 0.24 g, 4-nitroaniline: 0.28 g, ethyl 4-aminobenzoate: 0.33 g, 4-methoxyaniline: 0.25 g, 3,4-dimethoxyaniline: 0.31 g, 2-(methylthio)aniline: 0.25 mL, 2-aminobenzophenone: 0.39 g, 3-phenoxyaniline: 0.37 g, 3-(trifluoromethyl)aniline: 0.25 mL, 3-(trifluoromethoxy)aniline: 0.27 mL, naphthalene-1-amine: 0.29 g) was added (1.2 mL, 2.0 mmol) of T3P (Aldrich 50percent solution in EtOAc). If the mixture did not become a solution, (in the cases of the examples covered by entries 3 and 7 of Table 1) CH2Cl2 (2 mL) and EtOAc (2 mL) were added. After 5 min, (0.35 mL, 2.0 mmol) of P(OEt)3 was added and the mixture was stirred at 26 °C. After completion of the reaction (5?10 min), the mixture was diluted with EtOAc (15 mL) and washed with 10percent NaHCO3 solution (15 mL). The organic phase was dried (Na2SO4), filtered and concentrated. The residue was purified by flash chromatography on silica gel (Merck 107736 Silica gel 60H, CH2Cl2?MeOH) to afford products 3a?p.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Trifluoromethoxyaniline, other downstream synthetic routes, hurry up and to see.