Some common heterocyclic compound, 332-48-9, name is 1-(2-Bromoethoxy)-4-fluorobenzene, molecular formula is C8H8BrFO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 1-(2-Bromoethoxy)-4-fluorobenzene
A solution of 4-methyl-2-(2H-pyrazol-3-yl)-thiazole-5-carboxylic acid benzylamide (0.2 g, 0.67 mmol) in dimethyl sulfoxide (5 mL) was treated with 4-fluorophenoxyethyl bromide (0.14 g, 0.67 mmol) and potassium carbonate (0.30 g, 2.0 mmol), and the reaction mixture was heated to 90 0C for 16 hr. The reaction mixture was cooled to room temperature, diluted with ethyl acetate (50 mL), and washed with brine (2 x 50 mL). The organic phase was dried (Na2SC^) and evaporated. The residue was purified by preparative thin layer chromatography over silica gel (methylene chloride:methanol, 95:5) to provide 2-{l-[2-(4-fluoro-phenoxy)-ethyl]-lH-pyrazol-3-yl}-4-methyl-thiazole- 5-carboxylic acid benzylamide (0.071 g, 51% yield) as a white solid.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 332-48-9, its application will become more common.