In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 24878-25-9 as follows. Quality Control of 2,2′-Oxydianiline
A solution of 2-hydroxy-5-(thiophen-2-yl)benzaldehyde (3)(1.34 g, 2.0 mmol) in ethanol (30 mL) was added to a solution of2,20-oxydianiline (2-aminophenyl ether) (4) (0.66 g, 1.0 mmol) inethanol (20 mL) with continuous stirring, and the mixture wasrefluxed for 24 h. The completion of the reaction was monitoredthrough TLC. The reaction mixture was then cooled to room temperatureand ethanol was removed. The obtained residue waswashed with ethanol and dried at room temperature. The productwas recrystallized from the mixture of ethanol:kloroform (1:2). Theyield of orange product OPBTS was 46% (1.72 g), (m.p. 172-175 C).FTIR (KBr, cm-1) 3436.04 (nuO-H phenolic), 3268.00-3120.01 (nuAr C-H),1621.17 (nuCN), 1575.90e1489.00 (nuAr CC), 816.62 and 681.50 (nuC-SC).1H NMR (400 MHz, DMSO-d6) delta (ppm) 13.27 (s, 1H, ArO-H), 9.02(s, 1H, -CHN), 7.82 (d, 1H, J 2.4 Hz, Ar-H), 7.61 (dd, 1H, J 8.4,J 2.4 Hz, Ar-H), 7.55 (dd, 1H, J 7.4 Hz, J 1.8 Hz, Ar-H), 7.40 (dd,1H, J 5.2 Hz, J 1.2 Hz, Th-H), 7.30 (dd, 1H, J 3.6 Hz, J 1.2 Hz,Th-H), 7.26e7.23 (m, 2H, Ar-H), 7.04 (dd, 1H, J 5.2 Hz, J 3.6 Hz,Th-H), 6.94 (dd, 1H, J 8.0 Hz, J 1.6 Hz, Ar-H), 6.87 (d, 1H,J 8.8 Hz, Ar-H). 13C NMR (100 MHz, DMSO-d6) delta (ppm) 163.73,160.46,150.20,143.07,138.89,130.94,129.48,128.91,128.85,125.53,125.08, 123.03, 120.58, 119.82, 119.48, 117.92. Elemental anal. calcd.for C34H24N2O3S2: C, 71.31; H, 4.22; N, 4.89; O, 8.38; S,11.20%. FoundC, 70.86; H, 4.21; N, 4.90; S, 10.87%.
According to the analysis of related databases, 24878-25-9, the application of this compound in the production field has become more and more popular.