Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 22171-15-9, name is (4-(Benzyloxy)phenyl)methanamine, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 22171-15-9
Preparation Example A+-8. N-(4-Benzyloxy-benzyl)-6-(ethoxymethyl-amino)-nicotinamide To a solution of 6-aminonicotinic acid (130mg, 0.941 mmol) and 4-benzyloxy-benzylamine (201 mg, 0.941 mmol) described in Preparation Example 1 in N,N-dimethylformamide (5mL), was added benzotriazol-1-yl-tris(dimethylamino)phosphonium hexafluorophosphate (624mg, 1.41mmol) and triethylamine (394mul, 2.82mmol), and the solution was stirred for 40 minutes at 80C. Water and ethyl acetate were added to the reaction solution, which was then partitioned, and the organic layer was washed twice with water. The solvent was evaporated in vacuo, ethyl acetate was added to the residue, a white insoluble matter was collected by filtration, and 6-amino-N-(4-benzyloxy-benzyl)-nicotinamide (202mg, 0.606mmol, 64%) was obtained. To a solution of the resulting 6-amino-N-(4-benzyloxy-benzyl)-nicotinamide (200mg, 0.556mmol) in ethanol (10mL) were added 5,5-dimethylimidazophospho-2,4-dione (85mg, 0.66mmol) and 37% formaldehyde aqueous solution (1mL), and the solution was stirred for 1 hour under reflux. Water and ethyl acetate were added to the reaction solution, which was then partitioned, and the organic layer was washed twice. NH silica gel was added to the organic layer, the solvent was evaporated in vacuo for adsorption, purification was carried out by NH silica gel column chromatography (ethyl acetate), and the title compound (95mg, 0.243mmol, 40%) was obtained as a white solid. 1H-NMR Spectrum (CDCl3) delta (ppm) :1.20 (3H, t, J=7.0Hz), 3.55 (2H, q, J=7.0Hz), 4.56 (2H, d, J=5.5Hz), 4.84 (2H, s), 5.07 (2H, s), 5.68 (1 H, brs), 6.14 (1 H, brs), 6.62 (1 H, d, J=8.8Hz), 6.96 (2H, d, J=8.8Hz), 7.22-7.35 (4H, m), 7.27-7.44 (3H, m), 7.93 (1 H, dd, J=2.4, 8.8Hz), 8.54 (1 H, d, J=2.4Hz).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 22171-15-9.