Electric Literature of 162705-07-9,Some common heterocyclic compound, 162705-07-9, name is (Z)-2-Methoxy-5-(3,4,5-trimethoxystyryl)aniline, molecular formula is C18H21NO4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
3′ CA4-amine (0.11 g, 0.35 mmol) was dissolved in CH2Cl2 (10 mL), and then Fmoc-serine acetate (0.19 g, 0.52 mmol), T3P (0.62 mL, 1.0 mmol), and Et3N (0.073 mL, 0.52 mmol) were added. After stirring for 16 h at room temperature, water (10 mL) was added, and the reactionS3mixture was extracted with CH2Cl2 (3 × 10 mL). The combined organic phase was rinsed with brine, dried with Na2SO4, and concentrated under reduced pressure, and the residue was purified by flash column chromatography using a pre-packed 10 g silica column [solvent A: EtOAc; solvent B: hexanes; gradient: 12%A / 88%B (1 CV), 12%A / 88%B ? 100%A / 0%B (10 CV), 100%A / 0%B (2 CV); flow rate: 36 mL/min; monitored at 254 and 280 nm] affording the desired Fmoc-L-serinamide acetate 47 (0.22 g, 0.32 mmol, 93%) as a white solid.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (Z)-2-Methoxy-5-(3,4,5-trimethoxystyryl)aniline, its application will become more common.