Electric Literature of 450-88-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 450-88-4 name is 1-Bromo-4-fluoro-2-methoxybenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
EXAMPLE 1; Preparation of 5-(1,3-dihydroisoindol-2-ylcarbonyl)-3-(3-methylbenzyl)-6-hydroxy-1H-indazole (?A1?); 1.1; 12 ml of dichloromethane are added to 3.25 g of aluminium chloride under argon, and the mixture is cooled to -55 C. with stirring. A solution of 2.5 g of 2-bromo-5-fluoroanisole and 2.47 g of m-tolylacetyl chloride in 8 ml of dichloromethane is added dropwise at this temperature. The mixture is stirred for a further 10 minutes, allowed to warm slowly to 0 C. and subsequently hydrolysed using 1N HCl. The mixture is stirred for a further 15 minutes, diluted with dichloromethane and subjected to conventional work-up. The residue obtained is digested with petroleum ether/diethyl:ether (8:2), filtered off with suction and rinsed with petroleum ether. Drying gives 1.85 g of ?1a?
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Bromo-4-fluoro-2-methoxybenzene, and friends who are interested can also refer to it.