Application of 437-83-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 437-83-2 as follows.
Hydrobromic acid (48% in water, 140 mL) is added slowly to an aliquot of 11 (14.33 g, 101.5 mmol) cooled to 0 C. The resulting solid is broken up with a glass rod and stirred vigorously at 0 C for 10 min. A solution of sodium nitrite (7.4Og, 107.2 mmol) in water (50 mL) is added slowly (-1.5 h) to the stirred slurry containing 3-fluoro-2-methoxyphenylamine and hydrobromic acid, maintaining the temperature of the reaction mixture below 5 C. A purple solution of cuprous bromide (9.62 g, 67.1 mmol) in hydrobromic acid (48% in water, 50 mL) is added dropwise to the reaction mixture, maintaining the temperature of the reaction mixture below 5 C. The resulting reaction mixture is heated at 60 C until the evolution of gas ceases (~2.5 h). The reaction mixture is cooled to room temperature, and the product extracted with diethyl ether (6 x 150 mL). The combined organic extracts are washed with brine (3 x 150 mL), dried over magnesium sulfate, and evaporated under reduced pressure to give l-bromo-3-fluoro- 2-methoxybenzene as a brown oil. This product is of sufficient purity (>95% by NMR spectroscopy) to use directly in the next synthetic step. 1H NMR (CDCl3): 53.95 (d, JH-F = 1.5 Hz, 3H, OCH3), 6.88 (apparent t of d, JH_H = 8.0 Hz, JH-F = 5.5 Hz, IH, H-5), 7.04 (d, JH-F = 10.5 Hz, JH-H = 8.0 Hz, JH-H = 1.5 Hz,~lH, H-4), 7.30 (d of apparent t, JH_H = 8.0 Hz, JH-H = 1.5 EPO
According to the analysis of related databases, 437-83-2, the application of this compound in the production field has become more and more popular.