Reference of 104750-60-9, The chemical industry reduces the impact on the environment during synthesis 104750-60-9, name is 2-Bromo-1-(methoxymethoxy)-4-methylbenzene, I believe this compound will play a more active role in future production and life.
A solution of 9-bromoanthracene (0.67 g, 2.6 mmol, 1.2 eq) in dry Et2O (13 mL) under N2 was cooled to -30 C and “Buli (1.6 M in hexane, 1.6 mL, 2.6 mmol, 1.2 eq) was added dropwise. The solution was stirred for 20 min. at -30 C followed by dropwise addition of ZnCl2 (0.50 M in THF, 5.2 mL, 2.6 mmol, 1.2 eg). The reaction was stirred and warmed to RT over 30 min. The volatiles were removed under N2 purge and the residue was redissolved in 3:1 THF/NMP (11 mL). The MOM-protected bromophenol (2.2 mmol, 1.0 eg) and Pd(PtBu3)2 (22 mg, 44 mumol, 4 mol %) were added and the reaction was heated to 100 C for 2 h. The reaction was cooled to RT and the THF was removed. The residue was diluted with CH2C12, washed with 1 M HCI, and dried over Na2S04. The crude material was purified by flash chromatography. Synthesized by General Method Cl. Purified by flash chromatography (Biotage FLASH 40S KP-Sil silica, 0-5% EtzO/hexanes) to yield 0.59 g (84%) of 31 as a white solid. ?H NMR (CDCl3,300 MHz): 8.48 (s, 1H), 8.03 (d, J= 8.7 Hz, 2H), 7.65 (dd, J= 8.7 Hz, J = 0.6 Hz, 2H), 7.50-7.20 (m, 6H), 7.09 (d, J= 1.8 Hz, 1H), 4.84 (s, 2H), 3.00 (s, 3H), 2.38 (s, 3H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-1-(methoxymethoxy)-4-methylbenzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; SYMYX TECNOLOGIES, INC; WO2005/108406; (2005); A1;,
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