In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 127657-97-0 as follows. Formula: C11H16O3
D-tryptophan methyl ester hydrochloride (4.07 g, 16 mmol) and Intermediate 14 (3.75 g, 19 mmol) were combined with stirring in a solution of IPA (80 mL) and water (20 mL). To the resulting mixture was added 2N HCl (2 mL) and the resulting mixture heated at 70 C. for 18 hours. The mixture was neutralized with saturated aqueous NaHCO3, then extracted with methylene chloride (2¡Á400 mL). The combined organic extracts were dried over Na2SO4, filtered, and concentrated under reduced pressure. The residue was purified by flash column chromatography, eluting with methylene chloride/acetone (98:2), to provide the cis-carboline Intermediate 15 as an orange oil (1.5 g, 27%): TLC Rf (6:1 methylene chloride/ethyl acetate)=0.49; 1H NMR (300 MHz, CDCl3): delta: 8.46 (s, 1H), 7.50.(d, J=0.7 Hz, 1H), 7.47-7.25 (m, 6H), 7.18-7.06 (m, 2H), 4.65 (s, 2H), 4.44-4.39 (m, 2H), 3.88-3.82 (m, 1H), 3.81 (s, 3H), 3.66 (t, J=8.7 Hz, 1H), 3.18-3.11 (m, 1H), 2.88-2.78 (m, 1H), 1.87 (bs, 1H).
According to the analysis of related databases, 127657-97-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Orme, Mark W.; Schultze, Lisa M.; Sawyer, Jason Scott; Daugan, Alain Claude-Marie; Brown, Raymond; US2003/236263; (2003); A1;,
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