Related Products of 2982-54-9,Some common heterocyclic compound, 2982-54-9, name is 2-(4-(Benzyloxy)phenyl)ethanamine hydrochloride, molecular formula is C15H18ClNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a 100 ml flask as added lH-pyrrolo[3,2-c]pyridine-2-carboxylic acid (100 mg and 0.617 mmol) 2-(4-(benzyloxy)phenyl)ethanamine HC1 (195 mg, 0.740 mmol) in DMF (10 ml) to give a light yellow suspension. HATU (352 mg, 0.925 mmol) and DIEA (319 mg, 2.467 mmol) were added. The mixture was stirred at RT for 16 hours. Added water and extracted with ethyl acetate (3 x 20 mL). The organic layers were combined and washed with water (3 x 20 mL). The organic was separated, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure The Biotage purification affordedl40 mg of the product (61%). ¾ NMR (DMSO-d6). delta 13.00 (s, 1H), 9.30 (s, 1H), 9.00 (m, 1H), 8.37 (d, H), 7.78 (d, 1H), 7.52(s, 1H), 7.30-7.47 (m, 5H), 7.18(d, 2H), 6.90(d, 2H), 5.02(s, 2H), 3.37(m, 2H0, 2.80(m, 2H). LC-MS: 472.25 (M+l)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(4-(Benzyloxy)phenyl)ethanamine hydrochloride, its application will become more common.
Reference:
Patent; FORMA TM, LLC; BAIR, Kenneth W.; BAUMEISTER, Timm; BUCKMELTER, Alexandre J.; CLODFELTER, Karl H.; HAN, Bingsong; KUNTZ, Judith D.; LIN, Jian; REYNOLDS, Dominic J.; SMITH, Chase C.; WANG, Zhongguo; ZHENG, Xiaozhang; WO2012/154194; (2012); A1;,
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