In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 349-60-0, name is 1-Methoxy-3,5-bis(trifluoromethyl)benzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 1-Methoxy-3,5-bis(trifluoromethyl)benzene
In each of the examples in Table 3A, the substrate is reacted with the base in THF to form a metallic organoborate intermediate under the temperature and time conditions specified in Table 3A. The metallic organoborate intermediate is then reacted with the electrophile, E, in THF to form the functionalized products 11b to 11g under the following conditions:Furthermore, disubsituted anisole derivative such as lOf lead after metalation using 2b (25 °C, 0.5 h) followed by cross-coupling (ZnCl2 (10 molpercent), Pd(OAc)2 (3 molpercent), S-Phos (6 molpercent), 65 °C, 1 h) with 12 (0.8 equiv) to the functionalized anisole llf in 96percent yield (Table 3A, entry 6). In particular, tmpBEtyMgCl LiCl (2.2 mL, 1.0 M in THF, 2.2 mmol) was added dropwise at 25 °C to a solution of 3- bis(trifluoromethyl)anisole (lOf; 488 mg, 2.0 mmol) in THF (2 mL) in a flame-dried and Argon-flushed Schlenk-tube equipped with septum and magnetic stirring bar. After stirring for 30 min at 25 °C, ZnCl2 (0.2 mL, 1 M in THF, 10 molpercent), Pd(OAc)2 (14 mg, 3 molpercent), S-Phos (25 mg, 6 molpercent) and ethyl 4-iodobenzoate (12; 441 mg, 1.6 mmol) were added followed by continuously stirring for 1 h at 65 °C. After cooling to 25 °C, the reaction mixture was diluted with Et^O (5 mL) and quenched with sat. NH4C1 (aq.) (5 mL). The aqueous layer was extracted with CH2CI2 (3x 15 mL). The combined organic phases were dried over Na2SC>4 and the solvent was removed under vacuum. Flash column chromatography (pentane-Et^O, 95:5) afforded llf (602 mg, 96percent) as a white solid
The synthetic route of 349-60-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; HAAG, Benjamin; WO2012/85169; (2012); A1;,
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