Synthetic Route of 870563-60-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 870563-60-3, name is (4-Fluoro-2-methoxyphenyl)methanamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a stirred solution of ethyl 2-(l-bromo-2-ethoxy-2-oxoethyl)benzoate (Othman, M.; Decroix, B: Synth. Comm. 1996, 26, 2803) (945 mg, 3 mmol) in acetonitrile (15 mL) containing triethyl amine (835muL, 6 mmol) a solution of 4-fluoro-2-methoxybenzylamine (698 mg, 4.5 mmol) in acetonitrile (1 mL) was added dropwise under argon at O0C. The reaction, mixture was stirred at ambient temperature for 2 h. The mixture was diluted with ethyl acetate (50 mL), washed with water and brine. The organic phase was dried over magnesium sulfate and concentrated in vacuum. The residue was purified by column chromatography on silica gel using heptane/ethyl acetate (3:2) as an eluent to yield ethyl 2- (4-fluoro-2-methoxybenzyl)-3-oxoisoindoline-l-carboxylate as yellowish oil (857 mg, o/o).IH NMR (400 MHz, CDCl3) delta ppm 7.84 – 7.88 (m, 1 H), 7.67 – 7.76 (m, 1 H), 7.59 – 7.65 (m, 1 H), 7.46 – 7.58 (m, 2 H), 7.28 – 7.33 (m, 1 H)5 6.58 – 6.66 (m, 1 H), 5.21 (d, 1 H), 4.96 (s, 1 H), 4.47 (d, 1 H), 4.17 – 4.38 (m, 2 H), 3.82 (s, 3 H), 1.32 (q, 3 H) MS (ESI) m/z 344 [M+H], MS (ESI) m/z 342 [M-H]
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (4-Fluoro-2-methoxyphenyl)methanamine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ASTRAZENECA AB; WO2008/8020; (2008); A1;,
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