Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 888318-22-7, name is 1-Bromo-3,4-difluoro-2-methoxybenzene, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C7H5BrF2O
To a flask containing 1-bromo-3,4-difluoro-2-methoxy-benzene (1.0 g, 4.48 mmol) and 1,4-dioxa-8-azaspiro[4.5]decane (0.71 g, 4.93 mmol) in 1,4-dioxane (10 ml) was added tBuONa (1.3 g, 13.44 mmol), Pd2(dba)3 (82 mg, 0.09 mmol) and Ru-Phos (84 mg, 0.18 mmol)under N2. After being heated with stirring at 100 C overnight, the reaction mixture was cooled to rt, diluted with water (20 mL) and extracted with EA (30 mL) for three times. The combined organic layer was washed with brine, dried over anhydrous Na2SO4 and concentrated in vacuo to give 8- (3 ,4-difluoro-2-methoxy-phenyl)- 1 ,4-dioxa- 8-azaspiro [4.5] decane (0.74 g), which was used in the next step without further purification.
According to the analysis of related databases, 888318-22-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; CHENG, Zhanling; WANG, Min; YANG, Song; (208 pag.)WO2016/107832; (2016); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem