Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 17600-72-5, name is 1-Ethoxy-2-methoxybenzene, A new synthetic method of this compound is introduced below., Recommanded Product: 17600-72-5
10 g of the compound obtained in the preceding stage are cooled to -10 C., 21.84 ml of chlorosulfonic acid and then 13.68 g of phosphorus pentachloride are added dropwise and the mixture is left stirring at -5 C. for 1 hour. The reaction mixture is run onto 250 ml of ice and water and extracted with DCM, the organic phase is dried over Na2SO4 and the solvent is evaporated under vacuum. The residue is chromatographed on silica gel, elution being carried out with the gradient of the cyclohexane/AcOEt mixture from 95/5 (v/v) to 85/15 (v/v). The expected compound is obtained, M.p.=93 C. 1H NMR: CDCl3 (250 MHz): delta (ppm): 1.55, t, 3H, 3.99, s, 3H, 4.23, q, 2H, 6.97-7.02, mt, 1H, 7.46-7.48, mt, 1H, 7.66-7.71, mt, 1H.
The synthetic route of 17600-72-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SANOFI-AVENTIS; US2011/59955; (2011); A1;,
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