Related Products of 151414-47-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 151414-47-0, name is 2,6-Difluoro-4-methoxyaniline, This compound has unique chemical properties. The synthetic route is as follows.
Synthesis example 31 : A -(2,6-Difluoro-4-methoxy-phenyl)-5-(2,5-dimethoxyphenyl)-1-methyl-1H- pyrazole-3-carboxylic acid amide To a solution of intermediate 2b (72 mg) in dry toluene (2 mL) were consecutively added 2,6-difluoro-4- methoxyaniline (48 mg) and trimethyl aluminium (2 M in heptane, 0.15 mL) and the resulting mixture was heated to 110 C for 1 h. The mixture was chilled and 1 M HCI (2 mL) was added. The layers were separated and the aqueous layer was extracted with EtOAc. The combined organic layers were dried and the volatiles were removed under reduced pressure. The residue was purified through washing with Et20 to give the desired compound (86% yield). LC-MS (Method 2): m/z [M+Hf = 404.1 (MW calc. = 403.38); R, = 0.74 min
The chemical industry reduces the impact on the environment during synthesis 2,6-Difluoro-4-methoxyaniline. I believe this compound will play a more active role in future production and life.
Reference:
Patent; GRUeNENTHAL GMBH; NORDHOFF, Sonja; WACHTEN, Sebastian; KLESS, Achim; VOSS, Felix; RITTER, Stefanie; WO2014/108336; (2014); A1;,
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