Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 126940-10-1, name is 1-Fluoro-3-(methoxymethoxy)benzene, This compound has unique chemical properties. The synthetic route is as follows., category: ethers-buliding-blocks
To a solution of n-BuLi (76.85 ml_, 192.122 mmol, 1 eq) in THF (300 ml_) was added TMEDA (29.89 ml_, 99.807 mmol, 1 .04 eq) cooled to – 78C and stirred for 1 h. 1 -Fluoro-3-(methoxymethoxy)benzene (30 g, 192.122 mmol, 1 eq) in THF (75 ml_) was added to the mixture dropwise under argon, then the reaction mass was stirred for 2 hr at -78C, followed by addition of trimethylborate at the same temperature then slowly warmed to rt and stirred for 16 h. Then the reaction mass was cooled to 0C, then 30% H202 (18 mL) solution was added slowly dropwise. The reaction mass was warmed to rt and stirred for 1 h. TLC analysis indicated formation of a polar spot. The reaction mixture was dissolved in EtOAc (300 mL) and washed with brine (2×50 mL) and water (2×50 mL). The separated organic layer was dried over Na2S04 and concentrated under reduced pressure to afford crude product; which was purified by column chromatography (silica gel, 100-200mesh) using 8% EtOAc in petroleum ether as an eluent to afford 2-fluoro-6-(methoxymethoxy)phenol (25 g, 75.55%) as a colorless oil.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 126940-10-1.
Reference:
Patent; ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR); AL-AWAR, Rima; ISAAC, Methvin; CHAU, Anh My; MAMAI, Ahmed; WATSON, Iain; PODA, Gennady; SUBRAMANIAN, Pandiaraju; WILSON, Brian; UEHLING, David; (191 pag.)WO2019/119145; (2019); A1;,
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