Adding a certain compound to certain chemical reactions, such as: 151414-47-0, name is 2,6-Difluoro-4-methoxyaniline, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 151414-47-0, Recommanded Product: 151414-47-0
c) N-(2,6-difluoro-4-methoxyphenyl)-2-ri-(4-fluorophenyl)-3-r2-(4- methoxyphenyl)ethyll-5-oxo-2-sulfanylideneimidazolidin-4-yllacetamide (example 97) Oxalyl chloride (65 mu; 0.74 mmol; 2 eq) and dimethylformamide (1 drop) were added to a solution of 2-[l-(4-fluorophenyl)-3-[2-(4-methoxyphenyl)ethyl]-5-oxo-2- sulfanylideneimidazolidin-4-yl]acetic acid (1-21) (150 mg; 0.37 mmol; 1 eq) in dichloromethane (6 mL). The reaction mixture was stirred at room temperature for 2 hours. Then, 2,6-difluoro-4-methoxyaniline (T61) (89 mg; 0.56 mmol; 1.5 eq) and pyridine (90 mu; 1.11 mmol; 3 eq) were added. The reaction mixture was stirred at room temperature for 4 hours. Water (20 mL) was added and the aqueous layer was extracted with ethyl acetate (3 x 35 mL). The combined organic layers were washed with saturated sodium chloride (20 mL), dried over sodium sulfate, filtered and concentrated under reduced pressure. The crude was purified on silica gel using dichloromethane/ethyl acetate (95/5) as an eluent. After trituration in diethyl ether/ethanol the title compound N-(2,6-difluoro-4-methoxyphenyl)-2-[l-(4- fluorophenyl)-3-[2-(4-methoxyphenyl)ethyl]-5-oxo-2-sulfanylideneimidazolidin-4- yl]acetamide was obtained in 10% yield (20 mg) as a white powder. 1H-NMR (DMSO-d6): delta (ppm) 2.92 (m, 2H), 3.14 (m, 1H), 3.41 (m, 1H), 3.76 (m, 7H), 4.1 (m, 1H), 4.73 (s, 1H), 6.85 (m, 4H), 7.3 (m, 6H), 9.8 (s, 1H); MS (ESI+): m/z = 544.2 [M+H]+.
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Reference:
Patent; VIVALIS; GUEDAT, Philippe; BERECIBAR, Amaya; CIAPETTI, Paola; VENKATA PITHANI, Subhash; TROUCHE, Nathalie; WO2013/171281; (2013); A1;,
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