In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 239122-51-1, name is 5-Bromo-3-fluoro-2-methoxyaniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Product Details of 239122-51-1
Preparation of 3-amino-5-fluoro-4-methoxybenzonitrile[00165] A mixture of 5-bromo-3-fluoro-2-methoxyaniline (500 mg, 2.27 mmol), potassium ferrocyanide (II) hydrate (240 mg, 0.57 mmol), sodium carbonate (241 mg, 2.27 mmol) and palladium(II) acetate (25.5 mg, 0.11 mmol) in DMA (2 mL) was purged with nitrogen and heated at 120 0C for 6 hours. The reaction mixture was diluted with ethyl acetate (20 mL) and filtered through CELITE. The filtrate was washed with water (20 mL), 5% NH4OH (10 mL), dried over MgSO4, filtered and concentrated to isolate Intermediate 25 (213 mg, 56.4 % yield). HPLC: Rt = 0.73 min. (PHENOMENEX Luna 5 micron C18 4.6 x 30 mm, 10-90% aqueous methanol containing 0.1% TFA, 2 min. gradient, flow rate = 5 mL/min., detection at 254 nm). MS (ES): m/z = 167.2 [M+H]+. Intermediate 25 was used in the synthesis of Examples 234 and 239.
The synthetic route of 239122-51-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; FINK, Brian; CHEN, Libing; GAVAI, Ashvinikumar; HE, Liqi; KIM, Soong-Hoon; NATION, Andrew; ZHAO, Yufen; ZHANG, Litai; WO2010/42699; (2010); A1;,
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