Electric Literature of 4457-67-4, These common heterocyclic compound, 4457-67-4, name is 1-Bromo-4-methoxybutane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
(2) Production of 4′-methoxybutyloxybiphenyl-4-carboxylic acid 7.2 Grams of 1-bromo-4-methoxybutane and 4.5 g of 4′-hydroxybiphenyl-4-carboxylic acid were refluxed in 100 ml of water and 400 ml of ethanol for 4 hours. Concentrated hydrochloric acid was added to the reaction mixture so that the mixture showed pH 1, then 150 ml of water was added, and the resultant mixture was refluxed for 1 hour. The reaction mixture was cooled to precipitate a crystal, and the crystal was recovered by filtration. The so-obtained crystal was recrystallized from acetone. Yield 61percent.
Statistics shows that 1-Bromo-4-methoxybutane is playing an increasingly important role. we look forward to future research findings about 4457-67-4.
Reference:
Patent; Mitsubishi Gas Chemical Company, Inc.; US5340498; (1994); A;,
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