In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 870563-60-3, name is (4-Fluoro-2-methoxyphenyl)methanamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of (4-Fluoro-2-methoxyphenyl)methanamine
To a solution of 2-furaldehyde (41 muL, 0.5 mmol) in methanol (1.5 mL ) 4-fluoro-2- methoxybenzylamine (86 mg, 0.55 mmol), 2,6-dimethylphenyl isocyanide (72 mg, 0.55 mmol) and 2-butynoic acid (46 mg, 0.55 mmol) were added sequentially. The reaction mixture was stirred overnight. The volatiles were removed in vacuum and the residue was dissolved in dioxane (3 mL). Ytterbium trifluoromethanesulphonate (62 mg, 0.1 mmol) was added and the solution was heated at 1000C by microwave irradiation for 15 min. The mixture was cooled down to ambient temperature, filtered, and purified using preparative HPLC. The fractions containing the target compound were combined and extracted with
The synthetic route of 870563-60-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTRAZENECA AB; WO2008/8020; (2008); A1;,
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