Adding a certain compound to certain chemical reactions, such as: 53903-49-4, name is 4-Methoxy-2-(trifluoromethyl)aniline, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 53903-49-4, Quality Control of 4-Methoxy-2-(trifluoromethyl)aniline
Dissolve 4-methoxy-2-(trifluoromethyl)aniline (4.8 g, 25.1 mmol) in dichloromethane (10 mL),Triethylamine (5.0 g, 50.0 mmol) was addedAnd acetic anhydride (5.0 g, 50.0 mmol).The reaction solution was stirred at room temperature overnight.After the reaction was completed, water (100 mL) was added.Extract with dichloromethane (100 mL x 3).Combine the organic phase,The organic phase was washed with saturated brine (100 mL).Drying with anhydrous sodium sulfateConcentration under reduced pressure gave a grey solid.The gray solid was washed with a mixture of petroleum ether and ethyl acetate (20:1).A white solid was obtained (5.4 g, yield: 92.3%).
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Reference:
Patent; Tianjin Binjiang Pharmaceutical Research And Development Co., Ltd.; Tian Hongqi; Huang Gongchao; Cheng Ying; (48 pag.)CN107793413; (2018); A;,
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