Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4457-67-4, name is 1-Bromo-4-methoxybutane, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 1-Bromo-4-methoxybutane
d) Benzyl (3R,4R,5S)-3-hvdroxy-4-[4-(4-methoxy-butoxy)phenvH-5-thiso- propylsilanyloxy-piperidine-1-carboxylate; Analogously to method F, starting from benzyl (3R,4R,5S)-3-hydroxy-4-[4- hydroxyphenyl]-5-triiso-propylsilanyloxypiperidine-1 -carboxylate [873945-27-8] and 1 -bromo-4-methoxybutane [4457-67-4] the title compound is obtained as a yellow oil. Rt = 6.63 (gradient I).; General method F: (phenol alkylation I); The mixture of 20 mmol of “phenol” in 60 ml of N,N-dimethylformamide is stirred with 4.15 g of potassium carbonate and 30 mmol of “halide” or “tosylate” for 24 hours at 1000C. The reaction mixture is then evaporated. The residue is treated with 1 M aqueous sodium hydrogencarbonate solution (40 ml) and extracted with ethyl acetate (2 X 60 ml). The organic phases are washed with brine (1 X 60 ml), dried using sodium sulphate and evaporated. The title compound is obtained from the residue by means of flash chromatography (SiO2 60F).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 4457-67-4.
Reference:
Patent; Speedel Experimenta AG; WO2008/17685; (2008); A1;,
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