In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1187160-18-4 as follows. name: 7-Methoxy-2,3-dihydro-1H-inden-1-amine hydrochloride
To a stirred solution of ethyl 4-chloro-2-methyIthiopyrimidine-5-carboxylate (2.24 g, 9.62 mmol) in 35 mL of anhydrous tetrahydrofuran was added triethylamine (4.00 mL, 2.90 g, 28.72 mmol). The solution was cooled to 0-5 0C and 7-methoxy-l -aminoindane hydrochloride (2.00 g, 10.01 mmol) was added. The reaction mixture was allowed to warm to room temperature and stirred 48 h. The precipitate was filtered off, washed with ethyl acetate (1 x 25 mL), and the combined filtrates were evaporated to dryness. The residue was dissolved in dichloromethane (35 mL) washed with saturated sodium bicarbonate solution (1 x 17 mL), dried over magnesium sulfate, filtered and concentrated to give 4-(7-methoxy- 2,3-dihydro-l H-inden-l -ylamino)-2-(methylthio)pyrimidine-5-carboxylate as an oil (3.31 g, 9.21 mmol, 95%). ESMS m/z 360 (M+H)+; 1H NMR (400 MHz, CDCl3) delta ppm 8.63 (s, I H), 8.43 (d, J = 6.5 Hz, I H), 7.21 – 7.26 (m, I H), 6.88 (d, J= 7.5 Hz, I H), 6.72 (d, J= 8.3 Hz, I H), 5.69 – 5.78 (m, IH), 4.26 (q, J= 7.2 Hz, 2H), 3.78 (s, 3H), 3.01 – 3.13 (m, I H), 2.82 – 2.94 (m, I H), 2.59 – 2.67 (m, I H), 2.56 (s, 3H), 2.04 – 2.14 (m, IH), 1.33 (t, J= 7.2 Hz, 3H).
According to the analysis of related databases, 1187160-18-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; AFRAXIS, INC.; CAMPBELL, David; DURON, Sergio G.; VOLLRATH, Benedikt; WADE, Warren; WO2010/71846; (2010); A2;,
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