Adding a certain compound to certain chemical reactions, such as: 70894-71-2, name is N-(4-Methoxybenzyl)cyclopropanamine, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 70894-71-2, Recommanded Product: 70894-71-2
A solution of ethyl 6,8-dichloroimidazo[l ,2-b]pyridazine-3-carboxylate (4.0 g, 15.38 mmol), N-(4-methoxybenzyl)cyclopropanamine (4.09 g, 23.07 mmol) and diisopropylethyl amine (5.37 mL, 30.8 mmol) in tetrahydrofuran (THF, 5 mL) was refluxed at 70 C overnight. The reaction was concentrated and the crude product was purified using silica gel chromatography (25-30% ethyl acetate: petroleum ether), to provide ethyl 6-chloro-8-(cyclopropyl(4-methoxybenzyl)amino)imidazo[l ,2- b]pyridazine-3-carboxylate (4.3 g, 56% yield). 1H NMR (400 MHz, CHLOROFORM-D) delta ppm 8.14 (1 H, s), 7.05 – 7.07 (1 H, m), 7.02 – 7.05 (1 H, m), 6.76 – 6.79 (1 H, m), 6.74 – 6.76 (1 H, m), 6.60 (1 H, s), 5.61 (2 H, s), 4.43 (2 H, q, J=7.22 Hz), 3.75 (3 H, s), 2.45 – 2.54 (1 H, m), 1.41 (3 H, t, J=7.05 Hz), 0.96 – 1.04 (2 H, m), 0.76 – 0.84 (2 H, m). LC retention time 2.22 min [O]. MS (E+) m/z: 401 (MH+).
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Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WEINSTEIN, David S.; MOSLIN, Ryan M.; ZHANG, Yanlei; GARDNER, Daniel S.; SANTELLA, Joseph B.; LANGEVINE, Charles M.; STACHURA, Sylwia; (127 pag.)WO2017/87590; (2017); A1;,
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