Electric Literature of 1579-40-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1579-40-4 name is Di-p-tolyl Ether, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Tolyl ether (10 g, 0.05 mol), benzoic acid (7.5 g, 0.06 mol), zinc chloride (20 g, 0.15 mol) and phosphorus oxychloride (15 ml, 0.16 mol) were heated at 95C for two hours. The mixture was cooled to room temperature and ethyl acetate (25 ml) was added to form a suspension. The suspension was poured into 500 ml stirring DI water at room temperature. The mixture was heated under reflux for 15 minutes and cooled down to room temperature overnight. The mixture was filtered and washed with water (100ml). The damp cake was suspended with 300 ml of methanol and stirred to boil for 2 or 3 minutes. The resultant suspension was allowed to cool to room temperature over a period of 3 hrs and was then filtered, washed with methanol and dried to give the title compound as a solid (14 g, 91. 8%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Di-p-tolyl Ether, and friends who are interested can also refer to it.
Reference:
Patent; ISIS PHARMACEUTICALS, INC.; WO2005/77966; (2005); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem