Reference of 458-50-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 458-50-4 as follows.
At 0 deg.C, 1-bromo-2-fluoro-4-methoxybenzene (5.00 g, 24.39 mmol) in sulfuric acid (20.0 mL) solution was added portionwise potassium nitrate (2.47 g, 24.39 mmol). The reaction mixture was stirred at 0 deg.C for 0.5 h. TLC (petroleum ether: ethyl acetate = 3: 1) indicated the reaction was complete. The reaction mixture was added to ice water (50.0mL) in the quenched (100mL × 2) and extracted with EtOAc. The organic layer was dried over anhydrous sodium sulfate and filtered, and concentrated to dryness under reduced pressure to give the title compound (5.55 g, 90% yield) as a white solid.
According to the analysis of related databases, 458-50-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Nanjing Mingde New Drug Research and Development Co. Ltd.; Qilu Pharmaceutical Co., Ltd.; Ding, Zhaozhong; Zhang, Minghui; Chen, Shuhui; Liu, Xile; Zhu, Yidong; Fan, Chuanwen; Zhao, Baoping; Zhang, Long; Chen, Dong; Yang, Yingying; Zheng, Qingmei; Zheng, Shansong; Wan, Haiwen; Hu, Jinqing; (93 pag.)CN105330698; (2016); A;,
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