Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6943-97-1, name is 1-(3-Bromopropyl)-3-methoxybenzene, A new synthetic method of this compound is introduced below., HPLC of Formula: C10H13BrO
Step C Preparation of 2-[3-(3-Methoxy-phenyl)-propyl]-malonic acid diethyl ester Diethylmalonate (7.65 mL, 0.050 mol) was added slowly to a vigorously stirred suspension of pre-washed NaH (60%) (2.4 g, 0.050 mol) in dry DMF (50 mL) at 0 C. under Ar. After 15 min, 3-(3-methoxyphenyl)propylbromide (11.5 g, 0.050 mol) was added slowly, the ice bath was removed, and the reaction mixture was stirred at 65 C. for 16 hr. The mixture was cooled, partitioned between EtOAc (250 mL) and H2O (200 mL), the organic layer washed with H2O (2*500 mL), dried (Na2SO4), filtered, and concentrated to dryness to give the title compound. FAB MS(M+1) 309.1
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; deSolms, S. Jane; Stokker, Gerald E.; Shaw, Anthony W.; US2002/99007; (2002); A1;,
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