Synthetic Route of 701-07-5,Some common heterocyclic compound, 701-07-5, name is 2-(2′-Bromophenoxy)propane, molecular formula is C9H11BrO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
[066] 3-methyl-N-(7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,3,4,S-tetrahydro-1H-benzo[d]- azepin-7- amineprepared in Step 7 was used without further purification.Asolution of 3-methyl-N-(7H- pyrrolo[2,3-d]pyrimidin-2-yl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-amine from Step 7(65 mg, crude, about 0.22 mmol), 1-bromo-2-isopropoxybenzene (57 mg, 0.27 mmol), (trans)cyclohexane-1,2-diamine (7.5 mg, 0.066 mmol), Cul (12 mg, 0.066 mmol), and K3P04 (164 mg, 0.77 mmol) in dioxane (2 mL) was stirred at 120 C under nitrogen overnight. The mixture was diluted with water (5 mL), and extracted with EtOAc (20 mL). The organic layer was washed with brine (10 mL), dried over Na2504, filtered, and concentrated. The residue was purified byprep-TLC to give the title compound N-(7-(2-isopropoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-2- yl)-3-methyl-2,3,4,S-tetrahydro-1H-benzo[d]azepin-7-amine(9 mg, yield: 9%).
The synthetic route of 701-07-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CHANGZHOU JIEKAI PHARMATECH CO., LTD.; ZHANG, Jintao; XIANG, Yibin; XU, Wen; JIAN, Shanzhong; (40 pag.)WO2015/143692; (2015); A1;,
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