Reference of 4179-19-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4179-19-5, name is 3,5-Dimethoxytoluene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Stage 1 300 ml of a solution (1.6M) of butyllithium in hexane are added dropwise at room temperature to a solution of 73 g of 3,5-dimethoxytoluene in 450 ml of diethyl ether. The reaction mixture is heated at reflux for 3 hours under an inert atmosphere, the reaction mixture is then cooled to -60 C. and 99.7 g of methyl borate are added dropwise over 60 minutes. The reaction mixture is left at -60 C. for 3 hours and left to return to room temperature. The reaction mixture is stirred at room temperature for 16 hours, 6N hydrochloric acid is then added to the reaction mixture (pH=1) and the reaction mixture is left to separate by settling. The organic phase is recovered. The aqueous phase is extracted with diethyl ether. The combined organic phases are dried over anhydrous sodium sulphate. Evaporation of the solvent leaves a yellow oil which crystallizes by cooling to 0 C. After drying, white crystals of 2,6-dimethoxy-4-methylphenylboronic acid are recovered, M.p.=108 C., Yield 80%.
The synthetic route of 3,5-Dimethoxytoluene has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Sanofi; US5731340; (1998); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem