Reference of 54314-84-0, These common heterocyclic compound, 54314-84-0, name is ((3-Bromopropoxy)methyl)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Benzyl-3-bromopropyl ether(175 mL, 1.00 mmol) was dissolved in dimethylformamide(1 mL).N- (benzyloxycarbonyl) acetamide potassium salt(256 mg, 1.10 mmol), and the mixture was stirred at room temperature for 23 hours.The reaction was terminated by adding saturated aqueous ammonium chloride solution (about 3 mL)The reaction mixture was extracted with ethyl acetate.After washing the organic layer with water and saturated brine,And dried over anhydrous magnesium sulfate.Flash silica gel chromatography(10percent ethyl acetate / n-hexane)A colorless oil of N- (3- (benzyloxy) propyl) -N- (benzyloxycarbonyl) acetamide (311 mg, 91percent) was obtained.
Statistics shows that ((3-Bromopropoxy)methyl)benzene is playing an increasingly important role. we look forward to future research findings about 54314-84-0.
Reference:
Patent; School corporation Meijo University; Mori, Yuji; Sakai, Takeo; Fukuda, Ayumi; Kasai, Satomi; (28 pag.)JP2018/95576; (2018); A;,
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