In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 332-48-9, name is 1-(2-Bromoethoxy)-4-fluorobenzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Safety of 1-(2-Bromoethoxy)-4-fluorobenzene
Dissolve methyl 4-((15)-l-(((2R)-pyrrolidin-2-carbonyl)amino)ethyl)benzoate hydrochloride (1.00 g, 3.2 mmol) in DMF (8.0 mL) at room temperature, then add K2CO3 (1.33 g, 9.6 mmol) and l-(2-bromoethoxy)-4-fluorobenzene (715 mg, 3.2 mmol), then heat the mixture to 100 C with stirring overnight. Dilute the mixture with EtOAc (100 mL), and wash with a saturated aqueous solution of NaCl (2 chi 75 mL). Discard the aqueous layers, and dry the organic layer over MgS04, filter, and concentrate under reduced pressure to a volume of ca. 10 mL. Add hexanes (100 mL, then collect the resulting precipitate by filtration and rinse with hexanes (25 mL) and air-dry to furnish the title compound as a white solid (750 mg, 57% yield). Mass spectrum (m/z): 415 (M + H)+.
The synthetic route of 332-48-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ELI LILLY AND COMPANY; FISHER, Matthew Joseph; KUKLISH, Steven Lee; MANNINEN, Peter Rudolph; SCHIFFLER, Matthew Allen; WARSHAWSKY, Alan M; YORK, Jeremy Schulenburg; WO2015/94902; (2015); A1;,
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