Reference of 494-99-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 494-99-5, name is 1,2-Dimethoxy-4-methylbenzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
(a) 80.0 g (0.6 mole) of aluminium chloride are introduced in portions, while stirring, into a solution of 84.1 g (0.5 mole) of 1,2-dimethoxy-4-methylbenzene (homopyrocatechol dimethyl ether or 4-methylveratrole) in 750 ml of 1,2-dichloroethane, during which the temperature is maintained at 20 maximum by cooling with an ice bath. Then, at 15-20, 85.0 g (approximately 73 ml, 0.55 mole) of phenyl acetyl chloride are added dropwise in the course of one hour, during which there is moderate evolution of hydrogen chloride and the aluminium chloride is dissolved. The reaction mixture is then stirred at room temperature for a further 6 hours and subsequently poured into 3000 ml of a mixture of ice and water. The resulting layers are separated and the organic phase is washed in succession with 2N hydrochloric acid, twice with water, then with 1N sodium bicarbonate solution and a further twice with water, dried, filtered and concentrated by evaporation. The partially crystallized residue is caused to crystallise completely from ether/petroleum ether (boiling range 40-65), 1-(4,5-dimethoxy-2-methylphenyl)-2-phenyl-1-ethanone having a melting point of 45-48 being obtained.
The synthetic route of 1,2-Dimethoxy-4-methylbenzene has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Ciba-Geigy Corporation; US4500542; (1985); A;,
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