Related Products of 494-99-5,Some common heterocyclic compound, 494-99-5, name is 1,2-Dimethoxy-4-methylbenzene, molecular formula is C9H12O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
1 ,2-Dimethoxy-5-methyl-3,4-dinitro-benzene was synthesized by adding 15.0 g of 3,4- dimethoxytoluene portionwise to a mixture of 60 mL fumic nitric acid and 300 mL water keeping the temperature < 200C with the aid of an ice bath. The reaction was stirred for 1 h at 00C, quenched by the addition of ice and stirred for another 1 h. The yellow solid was filtered off, washed with ice cold water and dried in vacuo to yield 9.2 g of 1 ,2-dimethoxy- 5-methyl-3,4-dinitro-benzene as yellow solid.1H-NMR (CDCI3): 6.88 (s, 1 H); 4.01 (s, 3H); 3.98 (s, 3H); 2.52 (s, 3H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,2-Dimethoxy-4-methylbenzene, its application will become more common.
Reference:
Patent; ACTELION PHARMACEUTICALS LTD; WO2008/132679; (2008); A1;,
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