Application of 1462-37-9, The chemical industry reduces the impact on the environment during synthesis 1462-37-9, name is ((2-Bromoethoxy)methyl)benzene, I believe this compound will play a more active role in future production and life.
General procedure: To an oven-dried 5 mL screw-capped vial, in a glove box 2-methyl-N-(8-quinolinyl)benzamide (79 mg, 0.3 mmol), 1-bromobutane (82 mg, 0.6 mmol), Ni(OTf)2 (10.6 mg, 0.03 mmol), PPh3 (15.6 mg, 0.06 mmol), Na2CO3 (64 mg, 0.6 mmol) and toluene (1 mL) were added. The mixture was stirred for 24 h at 140 °C followed by cooling. The resulting mixture was filtered through a celite pad and concentrated in vacuo. The residue was purified by column chromatography on silica gel (eluent: hexane/EtOAc= 20/1) to afford the desired alkylated product (84 mg, 88percent) as a colorless oil.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, ((2-Bromoethoxy)methyl)benzene, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Aihara, Yoshinori; Wuelbern, Jendrik; Chatani, Naoto; Bulletin of the Chemical Society of Japan; vol. 88; 3; (2015); p. 438 – 446;,
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