6346-09-4, name is 4,4-Diethoxybutan-1-amine, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 6346-09-4
Triethylamine (25.6 mL, 185 mmol, 2 eq.) at 0 C was added to a solution of 4-aminobutyraldehyde diethyl acetal (15.0 g, 92.2 mmol, 1.0 eq.) in anhydrous dichloromethane (150 mL) under nitrogen atmosphere, and the reaction mixture was allowed to stir for 15 min, followed by dropwise addition of acetic anhydride (43.9 mL, 464 mmol, 5.0 eq.) at 0 C. The resulting reaction mixture was stirred for 2 h at 40 C. The resulting reaction mixture was quenched with a saturated aqueous solution of Na2CO3 (500 mL) and extracted with dichloromethane (100 mL × 4). The combined organic extract was dried over anhydrous Na2SO4 and concentrated under reduced pressure, yielding the desired compound B, (Fig. 1A, 15.5 g, 82% yield) as colorless oil. The compound was used as such in the next step without further characterization and confirmation.
The synthetic route of 6346-09-4 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Boutin, Jean A.; Bouillaud, Frederic; Janda, Elzbieta; Gacsalyi, Istvan; Guillaumet, Gerald; Hirsch, Etienne C.; Kane, Daniel A.; Nepveu, Francoise; Reybier, Karine; Dupuis, Philippe; Bertrand, Marc; Chhour, Monivan; Le Diguarher, Thierry; Antoine, Mathias; Brebner, Karen; Da Costa, Herve; Ducrot, Pierre; Giganti, Adeline; Goswami, Vishalgiri; Guedouari, Hala; Michel, Patrick P.; Patel, Aakash; Paysant, Jerome; Stojko, Johann; Viaud-Massuard, Marie-Claude; Ferry, Gilles; Molecular Pharmacology; vol. 95; 3; (2019); p. 269 – 285;,
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